The role of microRNAs in tumors

The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules tha...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 36; no. 10; pp. 1169 - 1177
Main Author Liu, Chuanxin
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.10.2013
대한약학회
Subjects
biomarkers
carcinogenesis
Carcinogenesis - genetics
Gene Expression Regulation, Neoplastic - genetics
genes
Humans
Medicine
microRNA
MicroRNAs - genetics
neoplasms
Pharmacology/Toxicology
Pharmacy
Review
약학
Tumorigenesis
MicroRNAs
Leukemia
Cancer
Apoptosis
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Summary:The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies.
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content type line 23
G704-000010.2013.36.10.001
ISSN:0253-6269
1976-3786
1976-3786
DOI:10.1007/s12272-013-0213-4