Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern

• Published in: Respiratory physiology & neurobiology Vol. 212; pp. 9 - 19
• Main Authors: Radocaj, Tomislav, Mustapic, Sanda, Prkic, Ivana, Stucke, Astrid G, Hopp, Francis A, Stuth, Eckehard A.E, Zuperku, Edward J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2015
• Subjects: 5-HT receptors; 5-HT1A receptors; 8-Hydroxy-2-(di-n-propylamino)tetralin - toxicity; 8-OH-DPAT; Action Potentials - drug effects; Analysis of Variance; Animals; Control of breathing; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Male; Medical Education; Medulla Oblongata - cytology; Medulla Oblongata - drug effects; Medulla Oblongata - metabolism; Microinjections; Neurons - drug effects; Phrenic Nerve - drug effects; Phrenic Nerve - physiology; preBötzinger complex; Pulmonary/Respiratory; Receptor, Serotonin, 5-HT1A - metabolism; Respiration - drug effects; Respiratory neurons; Serotonin - pharmacology; Serotonin Receptor Agonists - toxicity; Tachypnea - chemically induced; Tachypnea - pathology; Respiratory neurons; Control of breathing; preBötzinger complex; 5-HT 1A receptors; 5-HT receptors; 8-OH-DPAT; 5-HT1A receptors; 5-HT(1A) receptors
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2015.03.005

Highlights • Intravenous 5-HT1A receptor agonist 8-OH-DPAT induces brisk tachypnea in dogs. • Highly localized 8-OH-DPAT depresses preBötzinger region I and E neurons. • Ventral respiratory column 8-OH-DPAT injections induce no phrenic response. • Effects of Intravenous 8-OH-DPAT originate outside of the ventral respiratory column.