Opposing actions of TRPV4 channel activation in the lung vasculature

• Published in: Respiratory physiology & neurobiology Vol. 219; pp. 43 - 50
• Main Authors: Ke, Sun-Kui, Chen, Lan, Duan, Hong-Bing, Tu, Yuan-Rong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2015
• Subjects: Animals; Apamin - pharmacology; Cardiovascular Agents - pharmacology; Charybdotoxin - pharmacology; Enzyme Inhibitors - pharmacology; Intermediate conductance potassium channel (IKCa); Leucine - analogs & derivatives; Leucine - pharmacology; Lung - blood supply; Lung - drug effects; Lung - physiology; Lung perfusion; Male; Medical Education; Mice, Inbred C57BL; Models, Cardiovascular; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - metabolism; Potassium Channel Blockers - pharmacology; Potassium Channels - metabolism; Pulmonary artery; Pulmonary Artery - drug effects; Pulmonary Artery - physiology; Pulmonary Circulation - drug effects; Pulmonary Circulation - physiology; Pulmonary/Respiratory; Small conductance potassium channel (SKCa); Sulfonamides - pharmacology; Tissue Culture Techniques; TRPV Cation Channels - agonists; TRPV Cation Channels - antagonists & inhibitors; TRPV Cation Channels - metabolism; TRPV4; Vascular Resistance - drug effects; Vascular Resistance - physiology; Vasoconstriction - drug effects; Vasoconstriction - physiology; Vasodilation - drug effects; Vasodilation - physiology; NO; Intermediate conductance potassium channel (IK Ca); ACh; ChTx; endothelium-derived hyperpolarizing factor; intermediate conductance potassium channel; analysis of varianc; Small conductance potassium channel (SK Ca); ANOVA; epoxyeicosatrienoic acid; phenylephrine; reactive oxygen species; NG-nitro-l-arginine methyl ester; IK Ca; EC; EETs; Lung perfusion; L-NAME; nitric oxide; charybdotoxi; endothelial cell; physiological salt solution; transient receptor potential vanilloid 4; standard error; Pulmonary artery; PSS; SK Ca; small conductance potassium channel; PE; TRPV4; ROS; SEM; acetylcholine; EDHF; IKCa; Small conductance potassium channel (SKCa); SKCa; Intermediate conductance potassium channel (IKCa); Intermediate conductance potassium channel (IK(Ca)); Small conductance potassium channel (SK(Ca))
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2015.08.003

Graphical abstract