Progressive Transformation of Germinal Centers: Single Center Experience of 33 Turkish Patients

• Published in: Clinical lymphoma, myeloma and leukemia Vol. 16; pp. S149 - S151
• Main Authors: Özkan, Melda Cömert, Specialist, Özsan, Nazan, Associate Professor, Hekimgil, Mine, Professor, Saydam, Güray, Professor, Töbü, Mahmut, Professor
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016
• Subjects: Adult; Aged; Biomarkers; Biopsy; Cell Transformation, Neoplastic; Female; Germinal Center - metabolism; Germinal Center - pathology; Hematology, Oncology and Palliative Medicine; Histopathology; Hodgkin Disease - diagnosis; Hodgkin lymphoma; Humans; Immunohistochemistry; Immunohistology; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphanedopathy; Lymphoma - diagnosis; Lymphoma - therapy; Lymphoma, Large B-Cell, Diffuse - diagnosis; Male; Middle Aged; Non-Hodgkin lymphoma; Retrospective Studies; Tumor Burden; Turkey; Young Adult; Non-Hodgkin lymphoma; Immunohistology; Histopathology; Hodgkin lymphoma; Lymphanedopathy
• ISSN: 2152-2650; 2152-2669
• DOI: 10.1016/j.clml.2016.03.010

Abstract Background Progressive transformation of germinal centers (PTGC) is a benign disease of the lymph nodes which is rarely associated with Hodgkin disease (HD). Objectives To review the clinical and pathologic features of PTGC, and PTGC's relationship with lymphoid neoplasia in adult population. Patients and Methods The data of 33 patients who were diagnosed with PTCG were analyzed, retrospectively. Results Of 33 PTGC patients, 48.5% were male and 51.5% were female; patients had a mean age of 43.8 years at diagnosis. Most enlarged and excised lymph nodes (LN) were cervical and axillary. Diffuse large B cell lymphoma (DLBCL) and nodular lymphocyte predominant hodgkin lymphoma (NLPHL) was detected concurrent with PTGC in two cases. Also PTGC was detected 3 years after the diagnosis of DLBCL, NLPHL and T cell rich B cell lymphoma in 3 cases. There was no relapse in lymphoma cases and no progression to lymphoma was detected during follow-up of other patients. Conclusion PTGC is not considered as a premalignant entity but development of lymphoma have been reported rarely. If PTGC occurs in the follow-up process of lymphoma cases, follow-up intervals may be intensified.