Voltammetric determination of sibutramine in beverages and in pharmaceutical formulations

A simple and sensitive method has been proposed for the determination of sibutramine-HCl in energy drinks, green tea and pharmaceutical formulations using differential pulse voltammetry performed on a hanging mercury drop electrode. In the chosen experimental condition (Mcllvaine pH 4.0 buffer, 50 m...

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Bibliographic Details
Published inQuímica Nova Vol. 35; no. 5; pp. 988 - 992
Main Authors Carvalho, Juliana M., Silva, Andrea R. da, Cunha, Alessandra L. M. C. da, Aucélio, Ricardo Q., Alberti, André Luis M., Leandro, Katia C.
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 2012
Subjects
differential pulse voltammetry
pharmaceutical formulations
sibutramine
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Summary:A simple and sensitive method has been proposed for the determination of sibutramine-HCl in energy drinks, green tea and pharmaceutical formulations using differential pulse voltammetry performed on a hanging mercury drop electrode. In the chosen experimental condition (Mcllvaine pH 4.0 buffer, 50 mV pulse amplitude and 40 mV s-1 scan velocity), sibutramine-HCl presented a reversible behavior and a peak maximum at -80 mV. Detection limit was 0.4 mg L-1 and the working linear range extended up to 33.3 mg L-1 (r = 0.99). Analysis of real and fortified samples enabled recoveries between 91 and 102%. The electroanalytical method was compared with a HPLC method which indicated it accuracy.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422012000500023