Chemical constituents of the roots of Codonopsis lanceolata

• Published in: Archives of pharmacal research Vol. 41; no. 11; pp. 1082 - 1091
• Main Authors: Du, Young Eun, Lee, Jin Su, Kim, Hye Mi, Ahn, Ji-Hye, Jung, In Ho, Ryu, Jong Hoon, Choi, Jung-Hye, Jang, Dae Sik
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.11.2018; 대한약학회
• Subjects: alkaloids; Animals; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; cell viability; chemical composition; Codonopsis - chemistry; Codonopsis lanceolata; Humans; inhibitory concentration 50; macrophages; Macrophages - drug effects; Macrophages - metabolism; medicinal properties; Medicine; Mice; neoplasm cells; nitric oxide; Nitric Oxide - antagonists & inhibitors; ovarian neoplasms; Pharmacology/Toxicology; Pharmacy; phenolic compounds; Plant Roots - chemistry; polyacetylenes; RAW 264.7 Cells; Research Article; roots; saponins; Saponins - isolation & purification; Saponins - pharmacology; Triterpenes - isolation & purification; Triterpenes - pharmacology; 약학; Lancemasides; Nitric oxide; Ovarian cancer cells; Campanulaceae; Codonopsis lanceolate
• ISSN: 0253-6269; 1976-3786; 1976-3786
• DOI: 10.1007/s12272-018-1080-9

A new phenylpropanoid ( 1 ), a new alkaloid ( 11 ), and a new natural polyacetylene ( 17 ), together with nine phenolic compounds ( 2 – 10 ), five alkaloids ( 12 – 16 ), three polyacetylenes ( 18 – 20 ), three triterpenoidal saponins ( 21 – 23 ), one phenylethanoid glycoside ( 24) , and three hexyl glycosides ( 25 – 27 ) with previous known structures, were isolated from the roots of Codonopsis lanceolata . All of the isolates 1 – 27 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC 50 values < 50 μM). In A2780 cells, lancemaside A exhibited the most potent inhibitory effect on cell viability. This is the first report on the pharmacological activities of lancemaside B ( 22 ).