2-Thiophenecarboxylic acid hydrazide Derivatives: Synthesis and Anti-Tuberculosis Studies

One of the most frequent and widespread infectious diseases especially in developing countries is tuberculosis (TB). The number of TB drug resistant tend to increase, and there has been no new TB drug introduce since the 1960s. Six 2-Thiophenecarboxylic acid hydrazide derivatives were synthesized in...

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Published inIOP conference series. Materials Science and Engineering Vol. 349; no. 1; pp. 12039 - 12044
Main Authors Fahmi, M R G, Khumaidah, L, Ilmiah, T K, Fadlan, A, Santoso, M
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.04.2018
Subjects
Developing countries
Infectious diseases
LDCs
Tuberculosis
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Summary:One of the most frequent and widespread infectious diseases especially in developing countries is tuberculosis (TB). The number of TB drug resistant tend to increase, and there has been no new TB drug introduce since the 1960s. Six 2-Thiophenecarboxylic acid hydrazide derivatives were synthesized in 90-97% yields, and 2-thiophenecarbonylhydrazone-5, 7-dibromoisatin showed the highest activity in inhibiting M. tuberculosis H37Rv.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/349/1/012039