An expanded role for neuroimaging in the evaluation of memory impairment

Alzheimer disease affects millions of people worldwide. The neuropathologic process underlying this disease begins years, if not decades, before the onset of memory decline. Recent advances in neuroimaging suggest that it is now possible to detect Alzheimer-associated neuropathologic changes well be...

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Published inAmerican journal of neuroradiology : AJNR Vol. 34; no. 11; pp. 2075 - 2082
Main Authors Desikan, R S, Rafii, M S, Brewer, J B, Hess, C P
Format Journal Article
LanguageEnglish
Published United States American Society of Neuroradiology 01.11.2013
Subjects
Alzheimer Disease - complications
Alzheimer Disease - pathology
Brain - pathology
Evidence-Based Medicine
Humans
Image Enhancement - methods
Magnetic Resonance Imaging - methods
Memory Disorders - etiology
Memory Disorders - pathology
Methodologic s
Molecular Imaging - methods
Neuroimaging - methods
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Summary:Alzheimer disease affects millions of people worldwide. The neuropathologic process underlying this disease begins years, if not decades, before the onset of memory decline. Recent advances in neuroimaging suggest that it is now possible to detect Alzheimer-associated neuropathologic changes well before dementia onset. Here, we evaluate the role of recently developed in vivo biomarkers in the clinical evaluation of Alzheimer disease. We discuss how assessment strategies might incorporate neuroimaging markers to better inform patients, families, and clinicians when memory impairment prompts a search for diagnosis and management options.
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All authors contributed equally to this study.
ISSN:0195-6108
1936-959X
1936-959X
DOI:10.3174/ajnr.A3644