Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin

Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin...

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Published inRSC advances Vol. 6; no. 16; pp. 12959 - 12963
Main Authors Ishikawa, Aline A, Salazar, Jesus V, Salinas, Magaly, Gaitani, Cristiane M, Nurkiewicz, Timothy, Negrete, George R, Garcia, Carlos D
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Aerosols
Benchmarking
Encapsulation
Inhalers
Nanospheres
Strain
Streams
Tuberculosis
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Abstract Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.
AbstractList Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.
Author Negrete, George R
Gaitani, Cristiane M
Salazar, Jesus V
Garcia, Carlos D
Nurkiewicz, Timothy
Salinas, Magaly
Ishikawa, Aline A
AuthorAffiliation c Department of Chemistry, UT San Antonio, San Antonio, TX, USA
d Department of Physiology & Pharmacology, Center for Cardiovascular & Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA
e Department of Chemistry, Clemson University, Clemson, SC 29634, USA
a School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil
b Department of Physics and Astronomy, UT San Antonio, San Antonio, TX, USA
AuthorAffiliation_xml – name: d Department of Physiology & Pharmacology, Center for Cardiovascular & Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA
– name: e Department of Chemistry, Clemson University, Clemson, SC 29634, USA
– name: a School of Pharmaceutical Sciences of Ribeirão Preto, Ribeirao Preto, SP, Brazil
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  givenname: Jesus V
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  fullname: Salazar, Jesus V
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Snippet Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to...
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SubjectTerms Aerosols
Benchmarking
Encapsulation
Inhalers
Nanospheres
Strain
Streams
Tuberculosis
Title Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin
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