Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin

Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin...

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Bibliographic Details
Published inRSC advances Vol. 6; no. 16; pp. 12959 - 12963
Main Authors Ishikawa, Aline A, Salazar, Jesus V, Salinas, Magaly, Gaitani, Cristiane M, Nurkiewicz, Timothy, Negrete, George R, Garcia, Carlos D
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Aerosols
Benchmarking
Encapsulation
Inhalers
Nanospheres
Strain
Streams
Tuberculosis
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Summary:Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.
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ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra25044g