The Effect of Medicaments Used in Endodontic Regeneration Technique on the Dislocation Resistance of Mineral Trioxide Aggregate to Root Canal Dentin

• Published in: Journal of endodontics Vol. 40; no. 12; pp. 2041 - 2044
• Main Authors: Topçuoğlu, Hüseyin Sinan, DDS, PhD, Arslan, Hakan, DDS, PhD, Akçay, Merve, DDS, PhD, Saygili, Gökhan, DDS, Çakici, Fatih, DDS, PhD, Topçuoğlu, Gamze, DDS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Adhesiveness; Aluminum Compounds - chemistry; Anti-Bacterial Agents - chemistry; Calcium Compounds - chemistry; Calcium Hydroxide - chemistry; Cefaclor - chemistry; Ciprofloxacin - chemistry; Dental Bonding; Dental Pulp Cavity - ultrastructure; Dentin - ultrastructure; Dentistry; Dislocation resistance; Drug Combinations; Endocrinology & Metabolism; Humans; Materials Testing; medicament; Metronidazole - chemistry; mineral trioxide aggregate; Minocycline - chemistry; Oxides - chemistry; Random Allocation; Root Canal Irrigants - chemistry; Root Canal Preparation - methods; Silicates - chemistry; Sodium Hypochlorite - chemistry; Stress, Mechanical; Surface Properties; mineral trioxide aggregate; Dislocation resistance; medicament
• ISSN: 0099-2399; 1878-3554
• DOI: 10.1016/j.joen.2014.08.018

Abstract Introduction The aim of this study was to evaluate the effect of calcium hydroxide (CH) and antibiotic pastes, including a mixture of metronidazole and ciprofloxacin, with and without minocycline or cefaclor, on the dislocation resistance of mineral trioxide aggregate (MTA) to root dentin. Methods Eighty single-rooted human mandibular premolars were selected. The teeth were prepared by using the ProTaper system. The prepared teeth were then instrumented to a #6 Peeso reamer to obtain a standard internal diameter of 1.5 mm. The reamers were passed 1 mm beyond apex to simulate immature teeth. The specimens were then randomly divided into a control group (no intracanal medicament was used) and 4 experimental groups that were treated with an intracanal medicament: CH, double antibiotic paste (DAP) with metronidazole and ciprofloxacin, triple antibiotic paste (TAP) with minocycline, or TAP with cefaclor ( n = 16). After 3 weeks, the medicaments were removed, and approximately 3 mm of MTA was placed in the coronal third of the canals. A push-out test was used to measure the dislocation resistance between the root dentin and MTA. Data were analyzed by using one-way analysis of variance and Tukey post hoc tests. Results The dislocation resistance values of the CH, TAP with minocycline, and TAP with cefaclor groups were similar to those of the control group ( P > .05), whereas the DAP group had the lowest dislocation resistance when compared with the other groups ( P < .05). Overall, there was a predominance of cohesive failures between root dentin and MTA. Conclusions The results of this study indicate that the application of DAP as an intracanal medicament reduced the dislocation resistance of MTA to root dentin.