Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells
A new phenolic amide, named cis -terrestriamide ( 7 ), together with ten known compounds ( 1 – 6, 8 – 11 ), were isolated from the methanolic extract of the fruits of Tribulus terrestris . The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance sp...
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| Published in | Archives of pharmacal research Vol. 41; no. 2; pp. 192 - 195 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
Pharmaceutical Society of Korea
01.02.2018
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 1976-3786 |
| DOI | 10.1007/s12272-017-0984-0 |
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| Abstract | A new phenolic amide, named
cis
-terrestriamide (
7
), together with ten known compounds (
1
–
6, 8
–
11
), were isolated from the methanolic extract of the fruits of
Tribulus terrestris
. The structure of
7
was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds
1
,
2
,
5
,
6
,
8
,
9
, and
11
exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC
50
values of 18.7–49.4 μM. |
|---|---|
| AbstractList | A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC
values of 18.7-49.4 μM. A new phenolic amide, named cis-terrestriamide(7), together with ten known compounds (1–6, 8–11), wereisolated from the methanolic extract of the fruits ofTribulus terrestris. The structure of 7 was elucidated on thebasis of extensive analyses of 1D and 2D nuclear magneticresonance spectroscopic and high resolution mass spectrometrydata. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibitedinhibitory effects on the lipopolysaccharide-stimulatednitric oxide production in RAW 264.7 cells, with IC50values of 18.7–49.4 lM. KCI Citation Count: 8 A new phenolic amide, named cis -terrestriamide ( 7 ), together with ten known compounds ( 1 – 6, 8 – 11 ), were isolated from the methanolic extract of the fruits of Tribulus terrestris . The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1 , 2 , 5 , 6 , 8 , 9 , and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC 50 values of 18.7–49.4 μM. A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1–6, 8–11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC₅₀ values of 18.7–49.4 μM. A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7-49.4 μM.A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7-49.4 μM. |
| Author | Kim, Hyung Sik Hong, Jin Tae Hwang, Bang Yeon Jang, Hari Kim, Jun Gu Lee, Jin Woo Lee, Moon Soon Lee, Mi Kyeong Le, Thi Phuong Linh |
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| CitedBy_id | crossref_primary_10_3390_metabo13010034 crossref_primary_10_1016_j_bse_2023_104600 crossref_primary_10_1016_j_foodchem_2018_10_056 crossref_primary_10_3390_antiox10030370 crossref_primary_10_1080_14786419_2020_1713126 crossref_primary_10_2174_0929867328666210726094955 crossref_primary_10_1080_87559129_2022_2067172 crossref_primary_10_3390_molecules30061259 crossref_primary_10_1016_j_biopha_2020_110762 crossref_primary_10_1016_j_phytochem_2020_112648 crossref_primary_10_1097_HM9_0000000000000026 crossref_primary_10_3390_biom11121765 |
| Cites_doi | 10.1016/j.ejmech.2016.02.044 10.1016/j.bmc.2004.05.007 10.4103/0973-7847.125530 10.3390/molecules21040429 10.1016/j.phytochem.2014.08.003 10.1016/S0378-8741(02)00205-2 10.1016/S0031-9422(97)01086-8 10.1016/S0968-0896(03)00280-3 10.3892/ijmm.2015.2301 10.5012/bkcs.2013.34.10.3105 10.1023/B:BILE.0000035483.85790.f7 10.1055/s-2000-8609 10.1248/cpb.31.156 10.1016/S0031-9422(98)00123-X 10.1021/acs.jafc.6b05136 10.3109/10715762.2010.540576 10.1021/ja038043d 10.1007/s12272-010-2226-6 10.1055/s-2001-11650 10.1016/j.tetlet.2013.05.081 10.1016/j.cbi.2015.03.029 |
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| Keywords | Zygophyllaceae Phenolic amide, Nitric oxide production inhibitor Tribulus terrestris |
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| Snippet | A new phenolic amide, named
cis
-terrestriamide (
7
), together with ten known compounds (
1
–
6, 8
–
11
), were isolated from the methanolic extract of the... A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of... A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1–6, 8–11), were isolated from the methanolic extract of the fruits of... A new phenolic amide, named cis-terrestriamide(7), together with ten known compounds (1–6, 8–11), wereisolated from the methanolic extract of the fruits... |
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| SubjectTerms | amides Amides - chemistry Amides - isolation & purification Amides - pharmacology Animals fruits inhibitory concentration 50 mass spectrometry Medicine Mice nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism nuclear magnetic resonance spectroscopy Pharmacology/Toxicology Pharmacy Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology RAW 264.7 Cells Research Article Tribulus Tribulus terrestris 약학 |
| Title | Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells |
| URI | https://link.springer.com/article/10.1007/s12272-017-0984-0 https://www.ncbi.nlm.nih.gov/pubmed/29177586 https://www.proquest.com/docview/1969920644 https://www.proquest.com/docview/2045815488 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002315648 |
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| ispartofPNX | Archives of Pharmacal Research, 2018, 41(2), , pp.192-195 |
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