Eruptive nevi associated with medications (ENAMs)

• Published in: Journal of the American Academy of Dermatology Vol. 75; no. 5; pp. 1045 - 1052
• Main Authors: Perry, Benjamin M., DO, Nguyen, Anne, DO, Desmond, Bryce L., DO, Blattner, Collin M., DO, Thomas, R. Scott, DO, Young, R. John, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016
• Subjects: adverse effects; Antibodies, Monoclonal - adverse effects; Antineoplastic Agents - adverse effects; azathioprine; combination chemotherapy; Dermatology; Drug Eruptions - epidemiology; Drug Eruptions - etiology; drug reactions; eruptive nevi; eruptive nevi associated with medications; Humans; Immunosuppressive Agents - adverse effects; medication reactions; medication-associated nevi eruptions; medication-associated reactions; melanocytic nevi; Neoplasms, Multiple Primary - chemically induced; Neoplasms, Multiple Primary - epidemiology; Neoplasms, Second Primary - chemically induced; Neoplasms, Second Primary - epidemiology; nevi; nevi eruptions; Nevus, Pigmented - chemically induced; Nevus, Pigmented - epidemiology; Risk; rituximab; Skin Neoplasms - chemically induced; Skin Neoplasms - epidemiology; drug reactions; medication reactions; combination chemotherapy; azathioprine; medication-associated reactions; nevi eruptions; medication-associated nevi eruptions; eruptive nevi associated with medications; adverse effects; nevi; melanocytic nevi; rituximab; eruptive nevi
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2016.04.064

Eruptive melanocytic nevi have been reported in association with severe blistering diseases, renal transplantation, malignancy, AIDS, and medications. Eruptive nevi associated with medications have been reported with increasing frequency. Of particular interest are eruptive nevi associated with medications developing in association with biologic therapies, which we anticipate will continue to become more common as use of these medications continues to increase. We searched the databases PubMed/MEDLINE, Cochrane, and Cumulative Index to Nursing and Allied Health Literature for associated medications using the terms “eruptive nevi,” “melanocytic + medications,” and “nevi + medications” for relevant articles. We report the summary of our findings, which were used in defining what constitutes an eruptive nevi associated with medication and developing a classification system by medication type.