APOE Genotype Effects on Alzheimer's Disease Onset and Epidemiology

The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many p...

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Bibliographic Details
Published inJournal of molecular neuroscience Vol. 23; no. 3; pp. 157 - 166
Main Author Ashford, J. Wesson
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.01.2004
Subjects
Age Distribution
Age of Onset
Aged
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer Disease - mortality
Alzheimer Disease - physiopathology
Alzheimer's disease
Apolipoproteins E - genetics
Centers for Disease Control and Prevention (U.S.)
Epidemiology
Genotype
Genotype & phenotype
Humans
Risk Factors
United States - epidemiology
United States
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ISSN0895-8696
0895-8696
1559-1166
DOI10.1385/JMN:23:3:157

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Summary:The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with age.
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ISSN:0895-8696
0895-8696
1559-1166
DOI:10.1385/JMN:23:3:157