An examination of the hexokinase method for serum glucose assay using external quality assessment data

Hexokinase methods for serum glucose assay appeared to give slightly but consistently higher inter-laboratory coefficients of variation than all methods combined in the UK External Quality Assessment Scheme; their performance over a two-year period was therefore compared with that for three groups o...

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Bibliographic Details
Published inAnnals of clinical biochemistry Vol. 23 ( Pt 1); p. 92
Main Authors Westwood, A, Bullock, D G, Whitehead, T P
Format Journal Article
LanguageEnglish
Published England 01.01.1986
Subjects
Autoanalysis - instrumentation
Blood Glucose - analysis
Glucose Oxidase
Hexokinase
Humans
Substrate Specificity
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Summary:Hexokinase methods for serum glucose assay appeared to give slightly but consistently higher inter-laboratory coefficients of variation than all methods combined in the UK External Quality Assessment Scheme; their performance over a two-year period was therefore compared with that for three groups of glucose oxidase methods. This assessment showed no intrinsic inferiority in the hexokinase method. The greater variation may be due to the more heterogeneous group of instruments, particularly discrete analysers, on which the method is used. The Beckman Glucose Analyzer and Astra group (using a glucose oxidase method) showed the least inter-laboratory variability but also the lowest mean value. No comment is offered on the absolute accuracy of any of the methods.
ISSN:0004-5632
DOI:10.1177/000456328602300111