Analysis of Insulin Analogs and the Strategy of Their Further Development

We analyzed the structural properties of the peptide hormone insulin and described the mechanism of its physiological action, as well as effects of insulin in type 1 and 2 diabetes. Recently published data on the development of novel insulin preparations based on combining molecular design and genet...

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Published inBiochemistry (Moscow) Vol. 83; no. Suppl 1; pp. S146 - S162
Main Authors Selivanova, O. M., Grishin, S. Yu, Glyakina, A. V., Sadgyan, A. S., Ushakova, N. I., Galzitskaya, O. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2018
Springer
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Genetic aspects
Insulin
Life Sciences
Microbiology
Physiological aspects
Review
Structure
hyperglycemia
glycemic control
insulin fibrils
diabetes
insulin analogs
hypoglycemia
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Summary:We analyzed the structural properties of the peptide hormone insulin and described the mechanism of its physiological action, as well as effects of insulin in type 1 and 2 diabetes. Recently published data on the development of novel insulin preparations based on combining molecular design and genetic engineering approaches are presented. New strategies for creation of long-acting insulin analogs, the mechanisms of functioning of these analogs and their structure are discussed. Side effects of insulin preparations are described, including amyloidogenesis and possible mitogenic effect. The pathways for development of novel insulin analogs are outlined with regard to the current requirements for therapeutic preparations due to the wider occurrence of diabetes of both types.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918140122