Bronchoprotective and bronchodilatory effects of deep inspiration in rabbits subjected to bronchial challenge

• Published in: Journal of applied physiology (1985) Vol. 91; no. 6; pp. 2511 - 2516
• Main Authors: Gunst, S. J, Shen, X, Ramchandani, R, Tepper, R. S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.12.2001; American Physiological Society
• Subjects: Aging - physiology; Air breathing; Airway Resistance - drug effects; Animals; Biological and medical sciences; Bronchi - drug effects; Bronchi - physiology; Bronchial Provocation Tests; Bronchoconstriction - physiology; Bronchoconstrictor Agents - pharmacology; Fundamental and applied biological sciences. Psychology; Methacholine Chloride - pharmacology; Rabbits; Respiratory Physiological Phenomena; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics; Tidal Volume; Vertebrates: respiratory system; Bronchodilation; Rabbit; Smooth muscle; Bronchomotricity; Lagomorpha; Respiratory system; Ripening; Respiratory tract; In vivo; Vertebrata; Bronchoconstriction; Mammalia; Reactivity; Plasticity; Forced inspiration
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.2001.91.6.2511

Departments of 1  Cellular and Integrative Physiology and 2  Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46223 The effect of deep inspiration (DI) on airway responsiveness differs in asthmatic and normal human subjects. The mechanism for the effects of DI on airway responsiveness in vivo has not been identified. To elucidate potential mechanisms, we compared the effects of DI imposed before or during induced bronchoconstriction on the airway response to methacholine (MCh) in rabbits. The changes in airway resistance in response to intravenous MCh were continuously monitored. DI depressed the maximum response to MCh when imposed before or during the MCh challenge; however, the inhibitory effect of DI was greater when imposed during bronchoconstriction. Because immature rabbits have greater airway reactivity than mature rabbits, we compared the effects of DI on their airway responses. No differences were observed. Our results suggest that the mechanisms by which DI inhibits airway responsiveness do not depend on prior activation of airway smooth muscle (ASM). These results are consistent with the possibility that reorganization of the contractile apparatus caused by stretch of ASM during DI contributes to depression of the airway response. airway reactivity; volume history; maturation; smooth muscle plasticity