A Case of Oral Plasmablastic Lymphoma and Review of Current Trends in Oral Manifestations Associated With Human Immunodeficiency Virus Infection

• Published in: Journal of oral and maxillofacial surgery Vol. 72; no. 9; pp. 1729 - 1735
• Main Authors: Medel, Nicholas, DDS, MD, Hamao-Sakamoto, Aya, DDS, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2014
• Subjects: Acquired Immunodeficiency Syndrome - diagnosis; Dentistry; Epstein-Barr Virus Infections - diagnosis; Fatal Outcome; Gingival Neoplasms - diagnosis; Gingival Neoplasms - pathology; Humans; Lymphoma, AIDS-Related - diagnosis; Lymphoma, AIDS-Related - pathology; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - pathology; Male; Middle Aged; Plasma Cells - pathology; Surgery
• ISSN: 0278-2391; 1531-5053
• DOI: 10.1016/j.joms.2014.04.009

Plasmablastic lymphoma (PBL) is a rare and aggressive type of non-Hodgkin lymphoma that in 2000 was classified as a distinct type of lymphoma related to acquired immune deficiency syndrome by the World Health Organization after the first reports of the disease surfaced in 1997. PBL is strongly associated with human immunodeficiency virus (HIV) infection and often occurs within the oral cavity. Despite intensive chemotherapy regimens and combinational antiretroviral therapy, the prognosis of PBL in HIV-infected patients remains poor. This article describes a case of oral PBL and a literature review of current trends in oral manifestations associated with HIV infection.