Serum cyclophilin A concentrations in renal transplant recipients receiving cyclosporine A: clinical implications for gingival overgrowth

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 116; no. 4; pp. 447 - 454
• Main Authors: Jiang, Lei, MD, Gao, Ming Jing, MD, PhD, Zhou, Jie, MD, Zhao, Jing, MD, Zhao, Shu Wei, MD, PhD, Zhao, Yun Fu, MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.10.2013
• Subjects: Adult; Analysis of Variance; Cross-Sectional Studies; Cyclophilin A - blood; Cyclosporine - administration & dosage; Cyclosporine - adverse effects; Dental Plaque Index; Dentistry; Enzyme-Linked Immunosorbent Assay; Female; Gingival Overgrowth - chemically induced; Gingival Overgrowth - pathology; Humans; Immunosuppression - adverse effects; Immunosuppressive Agents - adverse effects; Kidney Transplantation; Luminescent Measurements; Male; Middle Aged; Severity of Illness Index; Surgery
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2013.06.021

Objective The aim of this study was to investigate the clinical factors in relation to the cyclosporine A (CsA) induced gingival overgrowth (GO). Study design Seventy-three participants were assigned as GO+ and GO−. Factors including demographic, pharmacological, gingival variables and the serum cyclophilin A (CyPA) concentration were analyzed. Results The occurrence of GO was 39.72%. Papillary bleeding index (PBI) had a significantly higher risk of GO than plaque index (PI), the ratio of CsA to CyPA, and serum CyPA concentration (odds ratio = 364.323, 25.791, 1.002, 0.096, respectively). The severity of GO correlated with PI, the ratio of CsA to CyPA, PBI, serum concentrations of CsA and CyPA ( r  = 0.366, 0.355, 0.344, 0.305, and −0.232, respectively). Conclusions Since a cross-sectional study is not able to explain whether plaque and inflammation are the cause or consequence of GO, the ratio of CsA to CyPA may be a valuable marker for predicting GO.