The effect of exogenous surfactant on alveolar interdependence

Highlights • Imaging of intact in vivo alveoli allowed to evaluate the effect of surfactant instillation. • Surfactant instillation increased surface area of alveoli <20,000 mm2 but decreased surface area for alveoli <20,000 mm2. • Surfactant decreased both surface tension and recoil pressure....

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Bibliographic Details
Published inRespiratory physiology & neurobiology Vol. 210; pp. 7 - 13
Main Authors Salito, Caterina, Aliverti, Andrea, Mazzuca, Enrico, Rivolta, Ilaria, Miserocchi, Giuseppe
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2015
Subjects
Alveolar mechanics
Animals
Biological Products - pharmacology
In-vivo microscopy imaging
Male
Medical Education
Organ Size
Phospholipids - pharmacology
Pulmonary Alveoli - anatomy & histology
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - physiology
Pulmonary Surfactants - pharmacology
Pulmonary/Respiratory
Rabbits
Respiration, Artificial
Surface Tension - drug effects
Surfactant
Time Factors
Tracheotomy
Surfactant
Alveolar mechanics
In-vivo microscopy imaging
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Summary:Highlights • Imaging of intact in vivo alveoli allowed to evaluate the effect of surfactant instillation. • Surfactant instillation increased surface area of alveoli <20,000 mm2 but decreased surface area for alveoli <20,000 mm2. • Surfactant decreased both surface tension and recoil pressure. • Inter-alveolar mechanical equilibrium was preserved despite differences in alveolar morphology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.01.009