Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications

• Published in: International journal of biological macromolecules Vol. 220; pp. 537 - 572
• Main Authors: Yadav, Nisha, Mudgal, Deeksha, Anand, Ritesh, Jindal, Simran, Mishra, Vivek
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022
• Subjects: Carbohydrate; Encapsulation; Nanocarriers. Drug delivery; Natural bioactives; Polysaccharides; Encapsulation; Nanocarriers. Drug delivery; Polysaccharides; Carbohydrate; Natural bioactives
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2022.08.098

Nowadays, nano/micro-encapsulation as a pioneering technique may significantly improve the bioavailability and durability of Natural bioactives. For this purpose, chitosan as a bioactive cationic natural polysaccharide has been frequently used as a carrier because of its distinct chemical and biological properties, including polycationic nature, biocompatibility, and biodegradability. Moreover, polysaccharide-based nano/micro-formulations are a new and extensive trend in scientific research and development in the disciplines of biomedicine, bioorganic/ medicinal chemistry, pharmaceutics, agrochemistry, and the food industry. It promises a new paradigm in drug delivery systems and nanocarrier formulations. This review aims to summarize current developments in approaches for designing innovative chitosan micro/nano-matrix, with an emphasis on the encapsulation of natural bioactives. The special emphasis led to a detailed integrative scientific achievement of the functionalities and abilities for encapsulating natural bioactives and mechanisms regulated in vitro/in vivo release in various biological/physiological environments. [Display omitted]