Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats

Highlights • Male F344 rats exposed to 400 mg/L potassium bromate in drinking water had increased kidney weights. • Hyaline droplets were observed in renal tubules of F344 rats exposed to 200–400 mg/L potassium bromate in drinking water. • There were no KBrO3 -related microscopic findings in the lun...

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Published inEnvironmental toxicology and pharmacology Vol. 36; no. 3; pp. 1227 - 1234
Main Authors Dodd, Darol E, Layko, Debra K, Cantwell, Katherine E, Willson, Gabrielle A, Thomas, Russell S
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2013
Subjects
Animals
Blood Chemical Analysis
Body Weight - drug effects
Bromates - toxicity
Drinking - drug effects
Emergency
Endpoint Determination
F344 rats
Hyaline droplets
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Liver - pathology
Male
No-Observed-Adverse-Effect Level
Organ Size - drug effects
Potassium bromate
Rats
Rats, Inbred F344
Thyroid Gland - pathology
Hyaline droplets
Potassium bromate
F344 rats
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Summary:Highlights • Male F344 rats exposed to 400 mg/L potassium bromate in drinking water had increased kidney weights. • Hyaline droplets were observed in renal tubules of F344 rats exposed to 200–400 mg/L potassium bromate in drinking water. • There were no KBrO3 -related microscopic findings in the lung, liver, thyroid, and tunica vaginalis. • A NOEL of 100 mg/L KBrO3 (8.1 mg/kg/day) was selected based on the absence of microscopic alterations in the kidney.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.10.005