Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats
Highlights • Male F344 rats exposed to 400 mg/L potassium bromate in drinking water had increased kidney weights. • Hyaline droplets were observed in renal tubules of F344 rats exposed to 200–400 mg/L potassium bromate in drinking water. • There were no KBrO3 -related microscopic findings in the lun...
Saved in:
Published in | Environmental toxicology and pharmacology Vol. 36; no. 3; pp. 1227 - 1234 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.11.2013
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Highlights • Male F344 rats exposed to 400 mg/L potassium bromate in drinking water had increased kidney weights. • Hyaline droplets were observed in renal tubules of F344 rats exposed to 200–400 mg/L potassium bromate in drinking water. • There were no KBrO3 -related microscopic findings in the lung, liver, thyroid, and tunica vaginalis. • A NOEL of 100 mg/L KBrO3 (8.1 mg/kg/day) was selected based on the absence of microscopic alterations in the kidney. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1382-6689 1872-7077 |
DOI: | 10.1016/j.etap.2013.10.005 |