Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 2; no. 24; pp. 3741 - 3744
• Main Authors: Murray, James, Nowak, Dominika, Pukenas, Laurynas, Azhar, Rizuan, Guillorit, Mathieu, Wälti, Christoph, Critchley, Kevin, Johnson, Steven, Bon, Robin S
• Format: Journal Article
• Language: English
• Published: England 28.06.2014
• Subjects: Alkanes; Biocompatibility; Biology; Compatibility; Conjugation; Handles; Monolayers; Solid phase synthesis

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demons...