Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols

We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demons...

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Bibliographic Details
Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 2; no. 24; pp. 3741 - 3744
Main Authors Murray, James, Nowak, Dominika, Pukenas, Laurynas, Azhar, Rizuan, Guillorit, Mathieu, Wälti, Christoph, Critchley, Kevin, Johnson, Steven, Bon, Robin S
Format Journal Article
LanguageEnglish
Published England 28.06.2014
Subjects
Alkanes
Biocompatibility
Biology
Compatibility
Conjugation
Handles
Monolayers
Solid phase synthesis
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Summary:We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT-OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT-OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.
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ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb00573b