Ovarian Ablation for Premenopausal Breast Cancer: A Review of Treatment Considerations and the Impact of Premature Menopause

Highlights • Ovarian ablation (OA) is an important treatment for premenopausal breast cancer. • The 5-year survival benefit of OA as an adjuvant therapy is limited (1.4-3.6%). • OA causes premature menopause resulting in side effects and mortality risks. • Women contemplating OA require a comprehens...

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Bibliographic Details
Published inCancer treatment reviews Vol. 55; pp. 26 - 35
Main Authors Nourmoussavi, Melica, MD, Pansegrau, Gary, MD, Popesku, Jason, PhD, Hammond, Geoffrey L., PhD, Kwon, Janice S., MD, Carey, Mark S., MD
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.04.2017
Subjects
Ablation Techniques
Antineoplastic Agents, Hormonal - therapeutic use
Breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - therapy
Estrogens - metabolism
Female
Gonadal Steroid Hormones - blood
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Hematology, Oncology and Palliative Medicine
Humans
Menopause, Premature
Ovarian ablation
Ovariectomy
Ovary - drug effects
Ovary - radiation effects
Ovary - surgery
Premature menopause
Premenopause
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Tamoxifen - therapeutic use
Premature Menopause
Breast Cancer
Ovarian Ablation
Breast cancer
Ovarian ablation
Premature menopause
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Summary:Highlights • Ovarian ablation (OA) is an important treatment for premenopausal breast cancer. • The 5-year survival benefit of OA as an adjuvant therapy is limited (1.4-3.6%). • OA causes premature menopause resulting in side effects and mortality risks. • Women contemplating OA require a comprehensive risk/benefit discussion.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2017.02.005