International analysis of the frequency and outcomes of NK/T-cell lymphomas

• Published in: Best practice & research. Clinical haematology Vol. 26; no. 1; pp. 23 - 32
• Main Authors: William, Basem M., MD, MRCP(UK), Armitage, James O., MD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2013
• Subjects: Adult; angioimmunoblastic T-cell lymphoma; Anthracyclines - therapeutic use; Antineoplastic Agents - therapeutic use; Asia - epidemiology; Europe - epidemiology; Gamma Rays - therapeutic use; geographic variation; Hematology, Oncology and Palliative Medicine; Humans; International Cooperation; International T-cell Lymphoma Project; Lymphoma, Extranodal NK-T-Cell - diagnosis; Lymphoma, Extranodal NK-T-Cell - mortality; Lymphoma, Extranodal NK-T-Cell - pathology; Lymphoma, Extranodal NK-T-Cell - therapy; Lymphoma, T-Cell, Peripheral - diagnosis; Lymphoma, T-Cell, Peripheral - mortality; Lymphoma, T-Cell, Peripheral - pathology; Lymphoma, T-Cell, Peripheral - therapy; Middle Aged; Natural Killer T-Cells - drug effects; Natural Killer T-Cells - pathology; NK-cell lymphoma; North America - epidemiology; peripheral T-cell lymphoma; Prognosis; Retrospective Studies; Survival Analysis; T-cell lymphoma; T-cell project; Asia; North America; Europe; NK-cell lymphoma; International T-cell Lymphoma Project; T-cell project; angioimmunoblastic T-cell lymphoma; peripheral T-cell lymphoma; geographic variation; prognosis; T-cell lymphoma
• ISSN: 1521-6926; 1532-1924
• DOI: 10.1016/j.beha.2013.04.003

Peripheral T-cell and NK-cell lymphomas are uncommon disorders accounting for 10–15% of all non-Hodgkin lymphomas (NHL). The NHL classification project represents the first attempt to systematically study the distribution of NHL subtypes based on a collaborative international effort and it confirmed the wide geographic variation in the frequency of different subtypes of PTCL. Subsequently, the International T-cell Lymphoma Project (ITLP), the largest collaborative international effort to date, reported prevalence and outcomes of 1314 cases of PTCL from 22 institutions worldwide with central pathology review. The ITLP consortium launched a prospective study, the T-cell project, in September 2006 aimed at collecting an exhaustive clinical and biologic data set on 1000 patients with PTCL for better definition of prognostic factors that would influence outcomes of these patients. This review aims to describe the difference in frequency and outcomes for various subtypes of PTCL based on these studies.