Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics

• Published in: Biomaterials science Vol. 3; no. 7; pp. 1061 - 1065
• Main Authors: Cai, Kaimin, Yen, Jonathan, Yin, Qian, Liu, Yang, Song, Ziyuan, Lezmi, Stéphane, Zhang, Yanfeng, Yang, Xujuan, Helferich, William G, Cheng, Jianjun
• Format: Journal Article
• Language: English
• Published: England 01.07.2015
• Subjects: Animals; Biomedical materials; Cell Survival - drug effects; Chains (polymeric); Chemistry, Pharmaceutical; Doxorubicin - chemistry; Doxorubicin - toxicity; Drug Carriers; Drug Delivery Systems; Drug Liberation; Effectiveness; Humans; In vivo testing; In vivo tests; MCF-7 Cells - chemistry; MCF-7 Cells - drug effects; Mice; Nanoparticles; Nanoparticles - chemistry; Oxidation-Reduction; Paclitaxel - chemistry; Paclitaxel - therapeutic use; Particle Size; Polyethylene Glycols - chemistry; Polymerization; Polymers - chemical synthesis; Polymers - chemistry; Surgical implants
• ISSN: 2047-4830; 2047-4849
• DOI: 10.1039/c4bm00452c

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.