Recent advances in nonlinear optics for bio-imaging applications

• Published in: Opto-Electronic Advances Vol. 3; no. 10; p. 200003
• Main Authors: Zhang, Silu, Liu, Liwei, Ren, Sheng, Li, Zilin, Zhao, Yihua, Yang, Zhigang, Hu, Rui, Qu, Junle
• Format: Journal Article
• Language: English
• Published: Chengdu Editorial Office of Opto-Electronic Advances 01.01.2020; Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518000, China; Institue of Optics and Electronics, Chinese Academy of Sciences
• Subjects: bio-imaging; Biological activity; Biological properties; Biomedical materials; chemical specific; Imaging; label-free; Lasers; Metabolism; microscopic imaging; Microscopy; Nanowires; Nonlinear optics; nonliner optics; Optical properties; Optics; Peptides; Photonics; Tissues; Trends; Zinc oxides; New York; United States > US; nonliner optics; bio-imaging; label-free; microscopic imaging; chemical specific
• ISSN: 2096-4579
• DOI: 10.29026/oea.2020.200003

Nonlinear optics, which is a subject for studying the interaction between intense light and materials, has great impact on various research fields. Since many structures in biological tissues exhibit strong nonlinear optical effects, nonlinear optics has been widely applied in biomedical studies. Especially in the aspect of bio-imaging, nonlinear optical techniques can provide rapid, label-free and chemically specific imaging of biological samples, which enable the investigation of biological processes and analysis of samples beyond other microscopy techniques. In this review, we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this filed. Our perspective of this field is also presented.