Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

• Published in: Polymers Vol. 14; no. 10; p. 2070
• Main Authors: Wang, Mengmeng, Zhang, Erwei, Yu, Chenrui, Liu, Dandan, Zhao, Shiguang, Xu, Maodong, Zhao, Xiaofeng, Yue, Wenjin, Nie, Guangjun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.05.2022; MDPI
• Subjects: Amino acids; Antiinfectives and antibacterials; Caustic soda; Chitosan; Crack propagation; Dendrobium officinale enzyme; Enzymes; Glutamic acid; hydrogel; Hydrogels; Molecular weight; Peptides; Permeability; Retention; Self-assembly; Skin care; Spectrum analysis; Stress concentration; Toughness; Water absorption; γ-poly(glutamic acid); China; Japan; chitosan; skin care; hydrogel; Dendrobium officinale enzyme; γ-poly(glutamic acid)
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym14102070

Hydrogels have been widespreadly used in various fields. But weak toughness has limited their further applications. In this study, enzyme (DOE) was explored to improve chitosan/γ-poly(glutamic acid) (CS/γ-PGA) hydrogel in the structure and properties. The results indicated that DOE with various sizes of ingredients can make multiple noncovalent crosslinks with the skeleton network of CS/γ-PGA, significantly changing the self-assembly of CS/γ-PGA/DOE hydrogel to form regular protuberance nanostructures, which exhibits stronger toughness and better behaviors for skin care. Particularly, 4% DOE enhanced the toughness of CS/γ-PGA/DOE hydrogel, increasing it by 116%. Meanwhile, water absorption, antioxygenation, antibacterial behavior and air permeability were increased by 39%, 97%, 27% and 52%.