Relationship among Serum Progestagens, Cortisol, and Prolactin in Pregnant and Cycling Asian Elephants in Thailand

• Published in: Veterinary sciences Vol. 9; no. 5; p. 244
• Main Authors: Towiboon, Patcharapa, Saenphet, Kanokporn, Tayapiwattana, Chatchai, Tangyuenyong, Siriwan, Watanabe, Gen, Mahasawangkul, Sittidet, Brown, Janine L, Thitaram, Chatchote
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2022; MDPI
• Subjects: Animal reproduction; Antibodies; Asian elephant; Breeding success; Camps; Cortisol; Elephants; Estrus cycle; Females; Gestation; Hormones; Infertility; ovarian cycle; Ovaries; Parturition; Pregnancy; progestagens; Prolactin; Stillbirth; Tourism; Thailand; United States > US; cortisol; ovarian cycle; prolactin; Asian elephant; progestagens; pregnancy
• ISSN: 2306-7381; 2306-7381
• DOI: 10.3390/vetsci9050244

The aim of this study was to examine relationships among serum progestagens, cortisol, and prolactin in pregnant and normal cycling Asian elephants living in tourist camps in northern Thailand. Samples were collected twice a month for 22 months from nine elephants. Of those, four were pregnant (24.3 ± 2.9 years of age; range 21−28 years) and five (20.2 ± 9.6 years; range 8−34 years) exhibited normal ovarian cycles based on serum progestagen analyses. Gestation was divided into three periods: 1st (week 1−31), 2nd (week 32−62), and 3rd (week 63 to parturition), while the estrous cycle was divided into the follicular and luteal phases. Serum progestagens were higher during the luteal phase of the cycle (p < 0.003), whereas cortisol and prolactin were similar. In pregnant elephants, there were no differences in serum progestagens or cortisol concentrations across the three gestational periods, whereas prolactin concentrations increased significantly during the 2nd and 3rd periods (p < 0.0001). By contrast, prolactin concentrations in nonpregnant elephants were consistently low throughout the ovarian cycle. In one cycling female, prolactin concentrations were similar to pregnant elephants, perhaps because she was an allomother to two calves. Another cycling female exhibited consistently elevated cortisol concentrations, 5 to 10 times higher than the other elephants. There were no correlations between serum progestagens, cortisol, and prolactin throughout gestation; however, serum progestagens and cortisol were positively related in cycling elephants (r = 0.386, p < 0.001). From our results, there were a number of individual differences in reproductive hormonal patterns, so it is important to develop personalized monitoring programs for each elephant to enhance breeding success and create sustaining captive populations of elephants in Asia.