Impaired Self-healing Capacity in Airway Epithelia Lacking Aquaporin-3

• Published in: Respiratory physiology & neurobiology Vol. 233; pp. 66 - 72
• Main Authors: Zhu, Hai-Xing, PhD, Zhou, Jie-Bai, MD, Zhu, Xiao-Dan, MD, Zhou, Jian, PhD, Li, Jing, PhD, Song, Yuan-Lin, MD, PhD, Bai, Chun-Xue, MD, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2016
• Subjects: Airway epithelial cells; Animals; Aquaporin; Aquaporin 3 - deficiency; Aquaporin 3 - genetics; Aquaporin 3 - pharmacology; Bronchi - cytology; Bronchi - injuries; Cell Line, Transformed; Cell Movement - drug effects; Cell Movement - genetics; Epithelial Cells - drug effects; Epithelial Cells - physiology; Epithelial Cells - ultrastructure; Epithelium - metabolism; Epithelium - ultrastructure; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Glycerol; Glycerol - metabolism; Glycerol - pharmacology; Humans; Injury; Medical Education; Mice; Mice, Inbred BALB C; Mice, Knockout; Microscopy, Electron; Naphthalenes - toxicity; Pulmonary/Respiratory; Repair; Time Factors; Wound Healing - drug effects; Wound Healing - genetics; AQP; scanning electron microscopy; repair; airway epithelial cells; siRNA; small interfering RNA; aquaporin; human bronchial epithelial cell; glycerol; HBEC; SEM; transmission electron microscopy; injury; TEM; Injury; Glycerol; Airway epithelial cells; Repair; Aquaporin
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2016.08.002

Highlights • Impaired in vivo airway epithelial repair in AQP3-/- mice. • Reduced cell migration in AQP3-konckdown epithelial cells. • Reduced glycerol and ATP contents in AQP3-/- airways. • Glycerol supplement corrects impaired injury repair and cell migration in airway epithelia