Treatment of gonorrhea with clavulanate-potentiated amoxicillin (Augmentin)

One hundred sixty-one patients with culture-proved Neisseria gonorrhoeae infection were treated with a single oral dose of amoxicillin trihydrate (3 g) and potassium clavulanate (Augmentin, 0.25 g). Of 153 patients infected with non-penicillinase-producing strains of N. gonorrhoeae, 139 (91%) were c...

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Bibliographic Details
Published inSexually transmitted diseases Vol. 12; no. 3; p. 163
Main Authors Munday, P E, Bingham, J S, Ison, C A, Erdman, Y J, Harris, J R, Easmon, C S
Format Journal Article
LanguageEnglish
Published United States 01.07.1985
Subjects
Administration, Oral
Adolescent
Adult
Aged
Amoxicillin - adverse effects
Amoxicillin - pharmacology
Amoxicillin - therapeutic use
Amoxicillin-Potassium Clavulanate Combination
Clavulanic Acids - adverse effects
Clavulanic Acids - pharmacology
Clavulanic Acids - therapeutic use
Clinical Trials as Topic
Drug Combinations
Female
Gonorrhea - drug therapy
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Neisseria gonorrhoeae - drug effects
Penicillinase - biosynthesis
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Summary:One hundred sixty-one patients with culture-proved Neisseria gonorrhoeae infection were treated with a single oral dose of amoxicillin trihydrate (3 g) and potassium clavulanate (Augmentin, 0.25 g). Of 153 patients infected with non-penicillinase-producing strains of N. gonorrhoeae, 139 (91%) were cured, and five (62.5%) of eight patients infected with penicillinase-producing N. gonorrhoeae were cured. Augmentin was successful in eradicating N. gonorrhoeae from the rectum; 30 (97%) of 31 such infections were cured.
ISSN:0148-5717
DOI:10.1097/00007435-198507000-00015