Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (...

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Published inGenetics and molecular biology Vol. 27; no. 4; pp. 496 - 499
Main Authors Brenna, Sylvia Michelina Fernandes, Silva, Ismael Dale Cotrin Guerreiro da, Zeferino, Luiz Carlos, Pereira, Julia, Martinez, Edson Zachaione, Syrjänen, Kari Juhani
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Genética 2004
Subjects
BIOCHEMISTRY & MOLECULAR BIOLOGY
cervix cancer
codon 72
genetic polymorphism
GENETICS & HEREDITY
human papillomavirus
p53 polymorphism
cervix cancer
p53 polymorphism
genetic polymorphism
human papillomavirus
codon 72
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Summary:The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
ISSN:1415-4757
1678-4685
1415-4757
1678-4685
DOI:10.1590/S1415-47572004000400005