AN EFFICIENT HPLC-UV METHOD FOR THE QUANTITATIVE DETERMINATION OF CEFADROXIL IN HUMAN PLASMA AND ITS APPLICATION IN PHARMACOKINETIC STUDIES

• Published in: Journal of liquid chromatography & related technologies Vol. 35; no. 13; pp. 1871 - 1881
• Main Authors: Kano, Eunice Kazue, Serra, Cristina Helena dos Reis, Koono, Eunice Emiko Mori, Fukuda, Kazuo, Porta, Valentina
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 01.08.2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Analysis; Bioavailability; Biological and medical sciences; cefadroxil; General pharmacology; HPLC; human plasma; Liquid chromatography; Medical sciences; Pharmacokinetics; Pharmacology. Drug treatments; quantification; Human; Validation; Biological fluid; Chemical analysis; quantification; Healthy subject; Lactam; Oral administration; HPLC chromatography; Bioavailability; Blood; Blood plasma; Cephalosporin derivatives; Antibiotic; Reversed phase chromatography; Ultraviolet detector; Cefadroxil; Antibacterial agent; Pharmacokinetics; HPLC; human plasma; Quantitative analysis

Cefadroxil is a semi-synthetic first-generation oral cephalosporin used in the treatment of mild to moderate infections of the respiratory and urinary tracts, skin and soft tissue infections. In this work a simple, rapid, economic and sensitive HPLC-UV method is described for the quantitative determ...