PGC-1 α plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells
Highlights • PGC-1 α expression increases under hypoxia in pulmonary artery endothelial cells. • Hypoxia-induced PGC-1 α is modulated by 15-HETE. • PGC-1 α mediates the anti-apoptotic effect of 15-HETE. • PGC-1 α regulates apoptosis via caspase and mitochondria pathway.
Saved in:
Published in | Respiratory physiology & neurobiology Vol. 205; pp. 84 - 91 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.01.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Highlights • PGC-1 α expression increases under hypoxia in pulmonary artery endothelial cells. • Hypoxia-induced PGC-1 α is modulated by 15-HETE. • PGC-1 α mediates the anti-apoptotic effect of 15-HETE. • PGC-1 α regulates apoptosis via caspase and mitochondria pathway. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1569-9048 1878-1519 |
DOI: | 10.1016/j.resp.2014.10.015 |