PGC-1 α plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells

Highlights • PGC-1 α expression increases under hypoxia in pulmonary artery endothelial cells. • Hypoxia-induced PGC-1 α is modulated by 15-HETE. • PGC-1 α mediates the anti-apoptotic effect of 15-HETE. • PGC-1 α regulates apoptosis via caspase and mitochondria pathway.

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Bibliographic Details
Published inRespiratory physiology & neurobiology Vol. 205; pp. 84 - 91
Main Authors Li, Jing, Zhang, Yueming, Liu, Ying, Shen, Tingting, Zhang, Hongyue, Xing, Yan, Zhu, Daling
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2015
Subjects
15-HETE
Animals
Apoptosis
Apoptosis - physiology
Blotting, Western
Cattle
Cell Hypoxia - drug effects
Cell Hypoxia - physiology
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Flow Cytometry
Hydroxyeicosatetraenoic Acids - metabolism
Hydroxyeicosatetraenoic Acids - pharmacology
Hypoxia
Immunohistochemistry
In Situ Nick-End Labeling
Medical Education
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
PGC-1α
Pulmonary Artery - metabolism
Pulmonary artery endothelial cells
Pulmonary/Respiratory
RNA, Small Interfering
Transcription Factors - metabolism
Transfection
15-HETE
Hypoxia
Pulmonary artery endothelial cells
PGC-1 α
Apoptosis
PGC-1α
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Summary:Highlights • PGC-1 α expression increases under hypoxia in pulmonary artery endothelial cells. • Hypoxia-induced PGC-1 α is modulated by 15-HETE. • PGC-1 α mediates the anti-apoptotic effect of 15-HETE. • PGC-1 α regulates apoptosis via caspase and mitochondria pathway.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.10.015