The role of common variants of ABCB1 and  CYP7A1 genes in serum lipid levels and lipid-lowering efficacy of statin treatment: A meta-analysis

• Published in: Journal of clinical lipidology Vol. 8; no. 6; pp. 618 - 629
• Main Authors: Li, Qing, MD, Hong, Jiang, PhD, Wu, Jian, MD, Huang, Zhen-Xing, MD, Li, Qing-Jie, MD, Yin, Rui-Xing, PhD, Lin, Quan-Zhen, MD, Wang, Fang, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2014
• Subjects: ABCB1; ATP Binding Cassette Transporter, Sub-Family B - genetics; Cardiovascular; Cholesterol 7-alpha-Hydroxylase - genetics; Cholesterol, LDL - blood; Cholesterol, LDL - genetics; CYP7A1; Dyslipidemias - drug therapy; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypolipidemic Agents - therapeutic use; Meta-analysis; Polymorphism, Single Nucleotide; Serum lipid level; Single-nucleotide polymorphisms; Statin; Treatment Outcome; Triglycerides - blood; Triglycerides - genetics; Serum lipid level; Single-nucleotide polymorphisms; ABCB1; Statin; CYP7A1; Meta-analysis
• ISSN: 1933-2874; 1876-4789
• DOI: 10.1016/j.jacl.2014.07.010

Background The relation between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment is inconsistent. Objective The purpose of this meta-analysis was to explore the associations between the ABCB1 and CYP7A1 genes and serum lipid levels and lipid-lowering efficacy of statin treatment. Methods MEDLINE, EMBASE, and the Cochrane Library databases were searched systematically for studies of associations between relevant single nucleotide polymorphisms C3435 T ( ABCB1 ), G2677 A/T ( ABCB1 ), and A-204C ( CYP7A1 ) and serum lipid levels or statin treatment. Associations were assessed in pooled data by calculating mean difference with 95% confidence intervals. Results Seventeen studies with 4890 patients were included in this meta-analysis. The “AA” group at A-204C ( CYP7A1 ) had lower serum total cholesterol (TC) levels than “AC + CC” group. The “AA” group at A-204C ( CYP7A1 ) had greater reduction in low-density lipoprotein cholesterol (LDL-C) with statin treatment than “AC + CC” group. The “GG” group at G2677 A/T ( ABCB1 ) had less reduction in TC and LDL-C with statin treatment than “non-GG” group. Conclusions The A-204C ( CYP7A1 ) polymorphism was associated with the level of TC and the lipid-lowering efficacy of statin treatment in the level of LDL-C. The G2677 A/T ( ABCB1) polymorphism was associated with the lipid-lowering efficacy of statin treatment in the levels of LDL-C and TC.