The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury

• Published in: Environmental toxicology and pharmacology Vol. 34; no. 1; pp. 81 - 86
• Main Authors: Gul, Husamettin, Uysal, Bulent, Cakir, Erdinc, Yaman, Halil, Macit, Enis, Yildirim, Ali Osman, Eyi, Yusuf Emrah, Kaldirim, Umit, Oztas, Emin, Akgul, Emin Ozgur, Cayci, Tuncer, Ozler, Mehmet, Topal, Turgut, Oter, Sukru, Korkmaz, Ahmet, Toygar, Mehmet, Demirbag, Suzi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2012
• Subjects: Acetaminophen; Acetaminophen - toxicity; Alanine Transaminase - metabolism; Analgesics, Non-Narcotic - toxicity; Animals; Aspartate Aminotransferases - metabolism; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Disease Models, Animal; Emergency; Glutathione Peroxidase - metabolism; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver injury; Male; Malondialdehyde - metabolism; Necrosis - chemically induced; Necrosis - drug therapy; Necrosis - metabolism; Necrosis - pathology; Neopterin; Neopterin - blood; Nitrates - blood; Nitrites - blood; Oxidative stress; Ozone - therapeutic use; Ozone therapy; Protective Agents - therapeutic use; Rats; Rats, Sprague-Dawley; Superoxide Dismutase - metabolism; Ozone therapy; Oxidative stress; Neopterin; Acetaminophen; Liver injury
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2012.02.006

Highlights ► We examined the protective effect of ozone on acetaminophen-induced hepatotoxicity. ► Ozone decreased liver necrosis due to acetaminophen. ► Ozone had beneficial effect on liver antioxidant enzymes activities. ► Ozone decreased serum neopterin level, an inflammatory marker of cell-mediated immunity. ► Ozone therapy might improve the outcome in acetaminophen induced liver injury.