Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics

High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we e...

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Published inNanomedicine Vol. 29; p. 102258
Main Authors Toubhans, Benoit, Gazze, Salvatore Andrea, Bissardon, Caroline, Bohic, Sylvain, Gourlan, Alexandra T., Gonzalez, Deyarina, Charlet, Laurent, Conlan, R. Steven, Francis, Lewis W.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.10.2020
Elsevier
Subjects
Life Sciences
Metastasis
Nanomechanics
Nanoparticles
Ovarian Cancer
Selenium
Nanoparticles
Ovarian Cancer
Selenium
Metastasis
Nanomechanics
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Summary:High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we evaluated inorganic selenium nanoparticles (SeNP), and found them effective in inhibiting ovarian cancer cell growth. In both SKOV-3 and OVCAR-3 ovarian cancer cell types SeNP treatment resulted in significant cytotoxicity. The two cell types displayed contrasting nanomechanical responses to SeNPs, with decreased surface roughness and membrane stiffness, characteristics of OVCAR-3 cell death. In SKOV-3, cell membrane surface roughness and stiffness increased, both properties associated with decreased metastatic potential. The beneficial effects of SeNPs on ovarian cancer cell death appear cell type dependent, and due to their low in vivo toxicity offer an exciting opportunity for future cancer treatment. Treatment of high grade serous ovarian cancer cells OVCAR-3 and SKOV-3 with coated selenium nanoparticles highlighted two opposite behaviors depending on the aggressiveness of the cell type. Biomechanical modifications in metastatic SKOV-3 and aggressive OVCAR-3 assessed by Atomic Force Microscopy measurement led to the decreased metastatic potential of SKOV-3 cells and decreased viability of OVCAR-3 cells. [Display omitted]
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ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2020.102258