Dental stem cells as an alternative source for cardiac regeneration

Abstract Dental tissues contains stem cells or progenitors that have high proliferative capacity, are clonogenic in vitro and demonstrate the ability to differentiate to multiple type cells involving neurons, bone, cartilage, fat and smooth muscle. Numerous experiments have demonstrated that the mul...

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Published inMedical hypotheses Vol. 81; no. 4; pp. 704 - 706
Main Authors Xin, Loo Zhang, Govindasamy, Vijayendran, Musa, Sabri, Abu Kasim, Noor Hayaty
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.10.2013
Subjects
Cardiovascular Diseases - therapy
Dental Pulp - cytology
Heart - physiology
Humans
Internal Medicine
Models, Biological
Myocardium - cytology
Myocytes, Cardiac - physiology
Neovascularization, Physiologic - physiology
Phosphatidylinositol 3-Kinases - metabolism
Pluripotent Stem Cells - transplantation
Proto-Oncogene Proteins c-akt - metabolism
Regeneration - physiology
Signal Transduction - physiology
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Summary:Abstract Dental tissues contains stem cells or progenitors that have high proliferative capacity, are clonogenic in vitro and demonstrate the ability to differentiate to multiple type cells involving neurons, bone, cartilage, fat and smooth muscle. Numerous experiments have demonstrated that the multipotent stem cells are not rejected by immune system and therefore it may be possible to use these cells in allogeneic settings. In addition, these remarkable cells are easily abundantly available couple with less invasive procedure in isolating comparing to bone marrow aspiration. Here we proposed dental stem cells as candidate for cardiac regeneration based on its immature characteristic and propensity towards cardiac lineage via PI3-Kinase/Aktsignalling pathway.
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ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2013.07.032