Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

ABSTRACT The objective of this study was to analyze the antioxidant activities of chitooligosaccharides (COS) both in vitro and in high-fat diet (HFD)-mouse model. In antioxidant assays in HFD-mouse model, mice were administered with normal diet, HFD, or HFD with 0.5% COS for six weeks. The administ...

Full description

Saved in:
Bibliographic Details
Published inRevista brasileira de zootecnia Vol. 45; no. 11; pp. 661 - 666
Main Authors Qu, Daofeng, Han, Jianzhong
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Zootecnia 01.11.2016
Subjects
AGRICULTURE, DAIRY & ANIMAL SCIENCE
COS
HFG
in vitro
mouse
radical scavenging
VETERINARY SCIENCES
HFG
mouse
radical scavenging
COS
in vitro
Online AccessGet full text

Cover

More Information
Summary:ABSTRACT The objective of this study was to analyze the antioxidant activities of chitooligosaccharides (COS) both in vitro and in high-fat diet (HFD)-mouse model. In antioxidant assays in HFD-mouse model, mice were administered with normal diet, HFD, or HFD with 0.5% COS for six weeks. The administration of HFD with 0.5% COS resulted in significant increase in the activity of superoxide dismutase, catalase, and glutathione peroxidase in stomach, liver, and serum of mice as compared with the HFD-fed group, which means that COS may have certain antioxidant activity and can restore the activity of the enzymes affected by the HFD. Through morphological measurements of the small intestinal mucosa, mice fed HFD showed decreased villus height compared with other groups. On the other hand, HFD with 0.5% COS group showed similar ratio of villus height to depth compared with control mice, indicating that intestinal integrity was improved when COS was added. Chitooligosaccharides have potent antioxidant activity that can protect mice from oxidative stress.
ISSN:1516-3598
1806-9290
1516-3598
DOI:10.1590/s1806-92902016001100004