Discrepant Trajectories of Impairment, Activity, and Participation Related to Upper-Limb Function in Patients With Breast Cancer

• Published in: Archives of physical medicine and rehabilitation Vol. 96; no. 12; pp. 2161 - 2168
• Main Authors: Yang, Eun Joo, MD, PhD, Kang, Eunyoung, MD, PhD, Kim, Sung-Won, MD, PhD, FACS, Lim, Jae-Young, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015
• Subjects: Activities of Daily Living; Adult; Breast Neoplasms - drug therapy; Breast Neoplasms - surgery; Cancer Care Facilities; Disability Evaluation; Female; Humans; International Classification of Functioning, Disability and Health; Longitudinal Studies; Mastectomy - adverse effects; Middle Aged; Physical Medicine and Rehabilitation; Physical Therapy Modalities; Prospective Studies; Quality of Life; Recovery of Function; Rehabilitation; Socioeconomic Factors; Time Factors; Upper extremity; Upper Extremity - physiopathology; International Classification of Functioning, Disability and Health; CI; Disabilities of the Arm, Shoulder, and Hand; confidence interval; Rehabilitation; Upper extremity; DASH; ICF
• ISSN: 0003-9993; 1532-821X
• DOI: 10.1016/j.apmr.2015.08.426

Abstract Objectives To explore upper-limb disability with respect to health outcomes, operationalized by Disabilities of the Arm, Shoulder, and Hand, and to identify factors associated with each element of upper-limb disability over a 2-year period in breast cancer survivors. Design Prospective cohort study. Setting University hospital cancer center. Participants Individuals (N=191) recruited from all the patients with newly diagnosed breast cancer before cancer surgery at a university hospital between April 2006 and March 2007. Interventions Not applicable. Main Outcome Measures We evaluated demographics, social variables, and upper-limb disability in a baseline assessment preoperatively. Follow-up evaluations were conducted in outpatient clinics 3 months after surgery and at 12 and 24 months after surgery. Linear regression models with the generalized estimating equations of the compound symmetry covariance structure were used. Results Time since surgery was inversely associated with the impairment items score (β=−.20; 95% confidence interval [CI], −.49 to −.08) and positively associated with the activity limitation items score (β=.59; 95% CI, .29–.88). The impact of upper-limb disability preoperatively on the items involving both the activity limitation and participation restrictions scores was positive (β=2.89; 95% CI, .76–5.02) after adjusting for demographic, treatment type, and socioeconomic factors. Conclusions Our study revealed that upper-limb impairment recovered with time after breast cancer surgery; however, upper-limb function-related activity and participation were reduced through 2 years after surgery.