HLA-DRB11501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis

• Published in: Multiple sclerosis Vol. 29; no. 3; p. 333
• Main Authors: Brownlee, Wallace J, Tur, Carmen, Manole, Andreea, Eshaghi, Arman, Prados, Ferran, Miszkiel, Katherine A, Wheeler-Kingshott, Claudia Am Gandini, Houlden, Henry, Ciccarelli, Olga
• Format: Journal Article
• Language: English
• Published: England 01.03.2023
• Subjects: genetics; Clinically isolated syndrome; prognosis; multiple sclerosis
• ISSN: 1477-0970
• DOI: 10.1177/13524585221130941

Whether genetic factors influence the long-term course of multiple sclerosis (MS) is unresolved. To determine the influence of on long-term disease course in a homogeneous cohort of clinically isolated syndrome (CIS) patients. One hundred seven patients underwent clinical and MRI assessment at the time of CIS and after 1, 3, 5 and 15 years. status was determined using Sanger sequencing and tagging of the rs3135388 polymorphism. Linear/Poisson mixed-effects models were used to investigate rates of change in EDSS and MRI measures based on status. -positive (  = 52) patients showed a faster rate of disability worsening compared with the -negative (  = 55) patients (annualised change in EDSS 0.14/year vs. 0.08/year,  < 0.025), and a greater annualised change in T2 lesion volume (adjusted difference 0.45 mL/year,  < 0.025), a higher number of gadolinium-enhancing lesions, and a faster rate of brain (adjusted difference -0.12%/year,  < 0.05) and spinal cord atrophy (adjusted difference -0.22 mm /year,  < 0.05). These findings provide evidence that the allele plays a role in MS severity, as measured by long-term disability worsening and a greater extent of inflammatory disease activity and tissue loss. may provide useful information when considering prognosis and treatment decisions in early relapse-onset MS.