A screen-printed electrochemical sensing platform surface modified with nanostructured ytterbium oxide nanoplates facilitating the electroanalytical sensing of the analgesic drugs acetaminophen and tramadol

• Published in: Mikrochimica acta (1966) Vol. 187; no. 2; p. 126
• Main Authors: Khairy, Mohamed, Banks, Craig E.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.02.2020; Springer
• Subjects: Acetaminophen; Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Electric properties; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Nanoparticles; Drug abuse; Lanthanide metal oxide; Analgesic; Addiction; Opioid; Nanozyme; Hepatotoxicity; Hydrothermal
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-020-4118-x

An electrochemical sensing platform based upon screen-printing electrodes (SPEs) modified with nanostructured lanthanide metal oxides facilitate the detection of the widely misused drugs acetaminophen (ACP) and tramadol (TRA). Among the metal oxides examined, Yb 2 O 3 nanoplates (NPs) were found to give rise to an optimal electrochemical response. The electroanalysis of ACP and TRA individually, and within mixtures, was performed using cyclic and differential pulse voltammetry. The ACP and TRA exhibited non-overlapping voltammetric signals at voltages of +0.30 and + 0.67 V (vs. Ag/AgCl; pH 9) using Yb 2 O 3 -SPEs. Pharmaceutical dosage forms and spiked human fluids were analyzed in wide linear concentration ranges of 0.25–654 and 0.50–115 μmol.L −1 with limits of detection (LOD) of 55 and 87 nmol.L −1 for ACP and TRA, respectively. The Yb 2 O 3 -SPEs offer a sensitive and chemically stable enzyme-free electrochemical platform for ACP and TRA assay. Graphical abstract Schematic presentation of one-shot electrochemical analysis of misused drugs, tramadol (TRA) and acetaminophen (ACP) by utilizing ytterbium oxide nanoplates modified screen-printed electrodes (Yb 2 O 3 -SPEs). The Yb 2 O 3 -SPEs showed interesting responses for ACP and TRA within pharmaceutical formulations and human fluids.