Catalytic Asymmetric Mannich-Type Reactions Using a Novel Chiral Iron Complex

Catalytic asymmetric Mannich‐type reactions using a novel chiral iron complex have been developed. The reactions proceeded smoothly in the presence of a catalyst prepared from iron(II) chloride, a BINOL derivative, and i‐Pr2NEt. The desired products were obtained in good yield with good to high enan...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 344; no. 9; pp. 929 - 931
Main Authors Yamashita, Yasuhiro, Ueno, Masaharu, Kuriyama, Yokusu, Kobayashi, Shū
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.10.2002
WILEY‐VCH Verlag
Wiley
Subjects
asymmetric catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
iron
Lewis acid
Mannich reaction
Physical Sciences
Science & Technology
Lewis acid
AQUA COMPLEXES
DIELS-ALDER REACTIONS
LIGANDS
Mannich reaction
iron
asymmetric catalysis
WATER
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Summary:Catalytic asymmetric Mannich‐type reactions using a novel chiral iron complex have been developed. The reactions proceeded smoothly in the presence of a catalyst prepared from iron(II) chloride, a BINOL derivative, and i‐Pr2NEt. The desired products were obtained in good yield with good to high enantioselectivity, when 3,3′‐I2BINOL was employed as a chiral ligand. A protic additive such as methanol facilitated the reactions effectively.
Bibliography:ArticleID:ADSC929
istex:832877610C85C0EF95DE122B2EDE187943585250
ark:/67375/WNG-3SQX99HB-M
ISSN:1615-4150
1615-4169
DOI:10.1002/1615-4169(200210)344:9<929::AID-ADSC929>3.0.CO;2-Z