Squalene Feeding in Experimental Atherosclerosis

The hydrocarbon squalene, which has been suggested as a precursor in the biosynthesis of cholesterol, was fed to rabbits to see whether cholesterol thus synthesized would be efficacious in producing atheromatous lesions. Rabbits on a 3 per cent squalene diet for seven weeks showed an increase in liv...

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Bibliographic Details
Published inCirculation research Vol. 2; no. 4; pp. 340 - 343
Main Authors Kritchevsky, David, Moyer, Arden W, Tesar, Walter C, Logan, John B, Brown, Raymond A, Richmond, Gilbert
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 01.07.1954
Subjects
Arteriosclerosis
Atherosclerosis
Humans
Old Medline
Squalene - pharmacology
ARTERIOSCLEROSIS/experimental
SQUALENE/effects
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Summary:The hydrocarbon squalene, which has been suggested as a precursor in the biosynthesis of cholesterol, was fed to rabbits to see whether cholesterol thus synthesized would be efficacious in producing atheromatous lesions. Rabbits on a 3 per cent squalene diet for seven weeks showed an increase in liver weight and liver nonsaponifiable material but no more atheroma than did controls. Animals on the same diet for 14 weeks showed an increase in the cholesterol-rich lipoproteins as determined in the ultracentrifuge. Addition of squalene in no way altered the atherogenic propensities of the cholesterol diet.
Bibliography:ObjectType-Article-1
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ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.2.4.340