Prostate carcinoma with neuroendocrine differentiation successfully treated by early detection with imaging examination

• Published in: IJU case reports Vol. 3; no. 6; pp. 282 - 285
• Main Authors: Kobayashi, Momoko, Hagiwara, Masahiro, Yamashita, Hideyuki, Ohbu, Makoto, Irie, Akira
• Format: Journal Article
• Language: English
• Published: Australia John Wiley & Sons, Inc 01.11.2020; John Wiley and Sons Inc; Wiley
• Subjects: Androgens; Biopsy; Cancer surgery; Case Report; Case Reports; Chemotherapy; Clinical outcomes; Endocrine therapy; immunohistochemistry; Magnetic resonance imaging; neuroendocrine carcinoma; Prostate; Prostate cancer; prostatectomy; prostate‐specific antigen; Radiation therapy; Surgery; Urological surgery; neuroendocrine carcinoma; prostatectomy; prostate cancer; immunohistochemistry; prostate‐specific antigen
• ISSN: 2577-171X; 2577-171X
• DOI: 10.1002/iju5.12219

Introduction Clinicopathological features of neuroendocrine differentiation of prostate carcinoma have not been totally clarified yet. It is known to be associated with poor prognosis. Case presentation A patient with growing prostate‐specific antigen was diagnosed with prostate carcinoma and treated by laparoscopic prostatectomy. The pathological examination revealed the neuroendocrine differentiation of the tumor. Early detection of prostate carcinoma with neuroendocrine differentiation can be difficult due to its low expression of prostate‐specific antigen. The imaging examination contributed to the early detection. In the follow‐up period of 2 years, the patient remains cancer free. Conclusion Recently, the treatment options for prostate carcinoma have been expanded. Precise assessment of immunohistochemical nature of the tumor may be helpful for individualized decision‐making.