Use of cyclodextrins for the enantioselective separation of ergot alkaloids by capillary zone electrophoresis

Ergot alkaloid enantiomer derivatives were resolved using capillary zone electrophoresis. The effect of cyclodextrins, added to the background electrolyte, on the migration time and the resolution was studied. Good separation for epimeric ergot alkaloid derivatives was also obtained using phosphate...

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Bibliographic Details
Published inElectrophoresis Vol. 13; no. 1-2; p. 39
Main Authors Fanali, S, Flieger, M, Steinerova, N, Nardi, A
Format Journal Article
LanguageEnglish
Published Germany 01.01.1992
Subjects
Cyclodextrins
Electrolytes
Electrophoresis - methods
Ergot Alkaloids - isolation & purification
Molecular Structure
Nicergoline - analysis
Stereoisomerism
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Summary:Ergot alkaloid enantiomer derivatives were resolved using capillary zone electrophoresis. The effect of cyclodextrins, added to the background electrolyte, on the migration time and the resolution was studied. Good separation for epimeric ergot alkaloid derivatives was also obtained using phosphate buffer at pH 2.5. Separation was improved by supplementing the background electrolyte with 30 mM of gamma-cyclodextrin. Good resolution of racemic ergot alkaloid derivatives in their enantiomers was achieved in a background electrolyte containing either beta-cyclodextrin or its derivative, or gamma-cyclodextrin.
ISSN:0173-0835
DOI:10.1002/elps.1150130108