Use of Ionic Liquids as Neoteric Solvents in the Synthesis of Fused Heterocycles

• Published in: Archiv der Pharmazie (Weinheim) Vol. 347; no. 8; pp. 540 - 551
• Main Authors: Nevagi, Reshma J., Dighe, Santosh N., Dighe, Satish N., Chaskar, Pratip K., Srinivasan, Kumar V., Jain, Kishor S.
• Format: Journal Article
• Language: English; German
• Published: Germany Blackwell Publishing Ltd 01.08.2014; Wiley Subscription Services, Inc
• Subjects: Combinatorial Chemistry Techniques - methods; Fused heterocycles; Heterocyclic Compounds - chemical synthesis; Heterocyclic Compounds - chemistry; Ionic liquids; Ionic Liquids - chemistry; Ions; Liquids; Molecular Structure; Neoteric solvents; Reaction media cum promoters; Solvents; Solvents - chemistry; Ionic liquids; Fused heterocycles; Reaction media cum promoters; Neoteric solvents
• ISSN: 0365-6233; 1521-4184
• DOI: 10.1002/ardp.201400018

Medicinal chemistry has been benefited by combinatorial chemistry and high‐throughput parallel synthesis. Ionic liquids reduce the materials and energy intensity of chemical processes and products, minimize or eliminate the dispersion of harmful chemicals in the environment, maximize the use of renewable resources and extend the durability and recyclability of products. It is possible to tune the physical and chemical properties by varying the nature of the cations and anions. Ionic liquids can be easily recovered, cleaned up, and reused repeatedly. This review gives an overview of the use of ionic liquids in the synthesis of a variety of five‐membered fused heterocycles like imidazoles, benzimidazoles, isatins, benzoxazoles, and benzthiazoles as well as six‐ and seven‐membered fused heterocycles like pyrans, quinolines, pyrazolopyridines, xanthenes, coumarins, carbolines, 1,3‐benzoxazine, benzothiazines, flavones, furo[2,3‐d]pyrimidines, and benzodiazepines.