Trifluoromethyl-Substituted Pyridines Through Displacement of Iodine by in situ Generated (Trifluoromethyl)copper

A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2‐Iodopyridines can be converted into 2‐(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3‐ and 4‐iodopyridines or 2‐bromopyridines are used as th...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2002; no. 2; pp. 327 - 330
Main Authors Cottet, Fabrice, Schlosser, Manfred
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.01.2002
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Organic
Copper
Fluorine
Nitrogen heterocycles
Physical Sciences
Science & Technology
copper
METALATION
LITHIATION
nitrogen heterocycles
POLYFLUOROALKYLATION
fluorine
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Summary:A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2‐Iodopyridines can be converted into 2‐(trifluoromethyl)pyridines almost quantitatively. In contrast, yields are moderate at best if 3‐ and 4‐iodopyridines or 2‐bromopyridines are used as the starting materials.
Bibliography:ark:/67375/WNG-NL5WZZ63-V
ArticleID:EJOC327
istex:333110D9A99BD9F001DFC7EE2C0357060D60F2D4
ISSN:1434-193X
1099-0690
DOI:10.1002/1099-0690(20021)2002:2<327::AID-EJOC327>3.0.CO;2-V