Absence of overexpression of p53 protein by intestinal carcinoid tumours

A recessive gene on chromosome 17 encodes a protein, known as p53, which normally acts to regulate the cell cycle, its mutation and overexpression being amongst the commonest genetic abnormalities in human malignant neoplasms. As detected by immunolabelling using the anti-p53 protein antibody D07, o...

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Bibliographic Details
Published inThe Journal of pathology Vol. 175; no. 4; p. 403
Main Authors O'Dowd, G, Gosney, J R
Format Journal Article
LanguageEnglish
Published England 01.04.1995
Subjects
Carcinoid Tumor - genetics
Carcinoid Tumor - metabolism
Gene Expression
Genes, p53
Humans
Immunoenzyme Techniques
Intestinal Neoplasms - genetics
Intestinal Neoplasms - metabolism
Neoplasm Proteins - biosynthesis
Tumor Suppressor Protein p53 - biosynthesis
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Summary:A recessive gene on chromosome 17 encodes a protein, known as p53, which normally acts to regulate the cell cycle, its mutation and overexpression being amongst the commonest genetic abnormalities in human malignant neoplasms. As detected by immunolabelling using the anti-p53 protein antibody D07, overexpression was absent from a series of 22 intestinal carcinoid tumours (ten ileal, nine appendiceal, and three colorectal), nine overtly malignant, but was readily demonstrable in five of five colorectal adenocarcinomas, five of six cloacogenic carcinomas, and four of five squamous carcinomas of the anal canal used as controls. These observations are in keeping with previous similar studies of pulmonary carcinoid tumours and suggest possible differences in the pathogenesis of such neoplasms in comparison with non-endocrine differentiated tumours arising at equivalent sites.
ISSN:0022-3417
DOI:10.1002/path.1711750407